Two classes of antiviral agents have been developed for prevention and treatment of influenza: the M2 channel inhibitors (amantadine and rimantadine), and the neuraminidase inhibitors (zanamivir and oseltamivir). Amantadine and rimantadine were the first generation of influenza antiviral agents. These compounds specifically block the ion channel function of the M2 protein of influenza A virus, […]
When a person is exposed to an influenza virus, the innate and subsequently the adaptive or specific immune response kicks in and provides defence against the invading virus. Depending on the nature of the virus and the effectiveness of the immune response, the infected individual suffers from more or less severe consequences of the influenza […]
Research demonstrated that the H7N9 virus was able to attach both in the upper and in the lower parts of the respiratory tract. Based on what is known from other influenza viruses, attachment to the upper part is important for efficient transmission. The ability to also attach to the lower parts of the respiratory tract, […]
Antiviral drugs against influenza are predominantly used for the treatment of influenza. Treatment with influenza antiviral drugs should be started as soon as possible when the first symptoms of the disease are recognized and definitely within 48 hours. It has been shown that the sooner the drugs are used, the more effective they are. When […]
With the current knowledge about influenza viruses in humans and animals, as well as the mechanisms that underlie the emergence of new pandemic viruses, it is reasonable to expect that also in the future influenza pandemics will emerge. However the unprecedented increase of our understanding of processes that determine the emergence of influenza viruses with […]
The influenza vaccine does not contain any live viruses and therefore cannot cause the illness. Flu vaccine manufacturers inactivate the viruses used in the vaccine during the production process, and batches of flu vaccine are tested to make sure they are safe.
Serious adverse reactions to the influenza vaccine are rare, with most common reactions being local redness and swelling at the injection site. Other mild symptoms including headache, mild fever and sore muscles may occur in a very small percentage of people vaccinated, but are limited to 24-48 hours duration. Allergic reactions may occur in people […]
The influenza vaccine can reduce the chances of getting the flu by 70%-90% in healthy adults. The vaccine may be somewhat less effective in elderly persons and very young children, but vaccination can still prevent serious complications (like pneumonia) and deaths related to the flu.
Influenza viruses have a great capacity to mutate and change. In light of this, a new vaccine is made every year to protect against the current strains. In addition, immunity provided by an influenza vaccine begins to fade after a year.
Anyone can contract influenza and being healthy does not protect against infection. For those at high risk of developing complications from influenza, infection can result in a deterioration of the chronic condition, hospitalisation or even death. Risk groups commonly include elderly persons (age 65 and above), persons with long-term medical conditions (asthma, diabetes, or heart […]